The company was founded in Parma in 1935 when Giacomo Chiesi, a chemist who dreamed of doing research, bought the Laboratorio Farmaceutico Parmense and embarked on his entrepreneurial adventure. In the early forties the laboratory started to expand and sell its products abroad, exporting drugs to Eritrea and Austria. However, in 1944 the war broke out and part of the company was destroyed during a bombing raid, bringing all activities to a stop until the war ended. When the laboratory resumed its activities, the first scientific collaborator was hired and Chiesi launched its first penicillin-based ointment. At the time, Giacomo Chiesi was considering buying some land to build a real factory. The new pharmaceutical factory was launched in 1955, had 50 employees and manufactured an extensive range of successful drugs. Following the success of Clenil, Chiesi’s interest extended to the anti-inflammatory and pain killer areas and in 1989 the company launched Brexin, a fast-acting anti-inflammatory with good gastric tolerability. Brexin was soon marketed in over 60 countries, certified for the United States market and now has an international patent. Almost ten years after the Brazilian adventure, the Group’s international expansion is very strong, both in the European and non-European countries. Since 1987, Chiesi has opened affiliates in Pakistan, France, Spain, Greece, the United Kingdom, Austria and the Eastern European countries, the United States, Germany, the Maghreb countries, Turkey, Bulgaria, China, and Scandinavia. The Group’s historical products, focussing on the respiratory and cardiovascular therapeutic areas, continue to be well-established, and new products for neonatal diseases, musculoskeletal and vascular disorders have also been launched. The third Chiesi generation joined the company between the end of the second and the beginning of the third millennium, at different times and with different roles: Alessandro, Andrea, Giacomo and Maria Paola. Their input opened up new lines of research and development: the Modulite® technology for respiratory products with eco-friendly sprays like Foster®, fixed anti-asthma combination in pressurised metered-dose inhaler with new propellants and the development of the NEXTHaler®, dry powder inhaler, considered the most innovative device in its class. In 2008, Chiesi entered as a pioneer in the world of regenerative medicine by founding Holostem Advanced Therapies Ltd, and in 2013, with the acquisition of the Danish biopharmaceutical company Zymenex, moved into biotechnology, positioning itself today at the height of innovation in the bio-pharmaceuticals sector.