Registration Date 1 Jul 2018
Revision Date 1 Jul 2018



Medicine Dentistry

Enamel matrix derivative


Wound healing Trauma Formation of strong bones Dentistry Periodontal regeneration


Induces true periodontal regeneration as evidenced by human histological studies. Easy to apply in difficult accessible defects and in minimal invasive procedures Shows less complications compared to membranes. Well researched and published in 800 scientific and 200 clinical publications Based on ten-year long-term evidence in intrabony and recession defects. Stimulates bone formation and angiogenesis. Available in three different volume sizes allowing flexible treatment options

Manufacturer's Description

Emdogain, enamel matrix derivative, has been scientifically proven to promote the predictable regeneration of lost periodontal hard and soft tissue.

Emdogain, enamel matrix derivative, has been scientifically proven to promote the predictable regeneration of lost periodontal hard and soft tissue. Regeneration has been described in the AAP Glossary of Terms (2001) as “the reproduction or reconstitution of a lost or injured part.” Periodontal regeneration has been defined as restoration of lost periodontium, the formation of new bone, new cementum, and a functionally oriented periodontal ligament. The only means of determining true periodontal regeneration is through the histological evaluation of sections obtained after treatment. Consistent histological findings have demonstrated that Emdogain has the ability to promote true periodontal regeneration.

Emdogain fools the body into forming new bone, cementum, and attachment fibers, hence promoting periodontal regeneration. It consists of a mixture of enamel matrix proteins and their derivatives, and propylene-glycolic-alginate (PGA) as a carrier. Enamel matrix proteins (amelogenins) are taken from developing porcine tooth buds. By reintroducing EMP, you are signaling a biologic response from the body to do what it did naturally during creation. Enamel matrix proteins are only in the body at this time of creation. In tooth development, the secretion of these proteins onto the developing root surface precedes the formation of tooth attachment. A similar action occurs when the proteins are placed on a root surface that has lost bone and attachment from disease. When applied to the root surface during surgery, these proteins assemble into an insoluble matrix layer that promotes the attachment of mesenchymal cells. These cells produce new matrix components and growth factors that participate in the regain of tooth attachment. Emodogain also has the ability to inhibit epithelial cell growth that could interfere with proper tissue and bone reformation.


The main component in Emdogain® is amelogenin, which assembles into an insoluble matrix under physiological conditions. The matrix has the proven ability to stimulate various cell types involved in the wound healing cascade of soft and hard tissues (mesenchymal stem cells, osteoblasts, fibroblasts, periodontal ligament cells and cementoblasts) towards a regenerative pattern.