Adenosine Deaminase (ADA)

ADA is a key enzyme of the purine metabolism and it is involved in the breakdown of adenosine into nucleic acids. In humans it is primarily involved in the development and maintenance of the immune system and high activities of ADA can be found in diseases related to increased cellular immunity. ADA deficiency results in severe combined immunodeficiency disease.

Recommended sample types are human EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, cerebrospinal fluid, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate.