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Registration Date 12 Apr 2020
Revision Date 12 Apr 2020
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3D Insert with Nanomesh

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Medicine Medical Supplies

Biomembrane

Applications

Use as simulated basement membrane in single or co-culture 3D in vitro models to better maintain cancer phenotype.
Medicine Cancer therapies Stem cell delivery Tumors Tissue engineering

Properties

Cell retention in applications requiring wet coating of ECM proteins such as laminin, fibronectin, growth factors, etc . Currently, the seeding efficiency of the scaffold is 88-95% under dry conditions. However, seeding efficiency drops when applying wet-protein coating prior to cell seeding. Electrospun fibers have shown to cause shape-induced osteogenic differentiation of mesenchymal stem cells. The 3D Insert with nano-mesh design combines 3D environment with nano technology. This product is ideal for use in bone tissue engineering studies.

Cancer phenotype maintenance Shape-induced osteogenic differentiation of mesenchymal stem cells

Manufacturer's Description

3D Insert-PS/PCL (Polystyrene/Polycaprolactone) with Nanomesh is developed by combining the benefit of nanofibers and micro-scale 3D scaffold structure to provide a unique feature for use in tumor and stem cell research applications.

The 3D Insert with Nanomesh offers both nano- and micro-scale geometry to recreate cancer epithelium and stroma tissue-like conditions. Applications of the 3D Insert Nanomesh are suited for monoculture and co-culture in vitro models for drug screening and epithelial-stromal invasion studies.