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PhosphatidylethanolamineCarboxylic acid-functionalized methoxy polyethylene glycol (MPEG-COOH) is a single-active PEG derivative one, can be used for modification of proteins, peptides, amino acids or other reactive chemical groups and other materials. PEG modification may improve the solubility and stability, reduce immunogenicity of proteins and peptides. It also inhibits non-specific binding of charged molecules in the surface modification.